Drugs used in constipation
Domperidone
Used in some situations but its clinical evidence base is poor.
Indication:
Treatemnt of GORD
Formulation:
Suspension 1mg/ml
Tablet 10mg
Suppository 30mg
Dose:
Oral 0.2-0.4mg/kg tds – qds (can increase to 0.6mg/kg tds – qds)
Rectal 1mg/kg (max tds) round to nearest possible dose
Side-effects:
Rash, extra pyramidal effects
Interactions:
Opiates decrease the effect of domperidone
Antimuscarinics decrease the effect of domperidone
Notes:
Extra-pyramidalside effects may occur such as jerking or abnormal movements.