Drugs used in paediatric IBD
Methotrexate
Drugs used in IBD Methotrexate This is used either orally or initially sub-cutaneously as an injection once a week as an anti-inflammatory and is usually used as a treatment prior to the use of things like Infliximab and Adalimumab. BOOK AN APPOINTMENT Drugs used in paediatric inflammatory bowel disease Adalimumab Azathioprine Budesonide (Entocort CR) Cyclosporin…
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Drugs used in IBD Sulphasalazine Indication: Treatment of mild to moderate Ulcerative colitis and Crohns disease Formulation: Suspension 250mg/5ml Tablets 500mg, 500mg E/C Dose: Acute 10-15mg/kg QDS (max 4-8g daily) Doses will be adjusted to ensure ease of administration with the above formulations Side-effects: Nausea, vomiting, diarrhoea, abdominal pain, headache, exacerbation of colitis symptoms, rarely…
Read MorePrednisolone
Drugs used in IBD Prednisolone Indication: Reduce inflammation in acute attacks of Crohns and Ulcerative colitis. Maintain remission of the above. Formulations: Prednisolone Tabs 1mg, 5mg, 25mg Soluble 5mg Methylprednisolone succinate Inj 40mg, 125mg, 500mg, 1g Dose: Acute inflammation. Prednisolone 2mg/kg daily (max 40mg) (if used >7days, decrease over 14 days) Hydrocortisone is required to…
Read MorePrednisolone enemas
Drugs used in IBD Prednisolone enemas Indication: Reduce inflammation in acute attacks of Crohns and Ulcerative colitis. Maintain remission of the above. Formulation: Predfoam (Foam enema 20mg – 14 applications) Predsol retention enema (20mg in 100ml – single nozzle application) Prednisolone soluble tablets 5mg Dissolve the dose in 20 to 50ml of water and administer…
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Drugs used in IBD Olsalazine Indication: Treatment of mild to moderate Ulcerative colitis and Crohns disease Site of action: Colon Olsalazine consists of two molecules of mesalazine bound together. Colonic bacteria cleave this bond to release mesalazine. Formulations: Capsules 250mg, 500mg Dose: Acute 20mg/kg BD or 13mg/kg TDS ( max 3g as a total daily…
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Drugs used in IBD Mesalazine (Pentasa®) Indication: Treatment of mild to moderate Ulcerative colitis and Crohns disease Site of action: Duodenum, jejunum, ileum and colon. Formulations: Tablets 250mg, 500mg Enema 1g/100ml Suppositories 1g Dose: Acute 25mg/kg BD or 17mg/kg TDS ( max 3g-4g as total daily dose) Doses will be adjusted to ensure ease of…
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Drugs used in IBD Mesalazine (Asacol®) Indication: Treatment of mild to moderate Ulcerative colitis and Crohns disease Site of action: Terminal ileum and proximal colon Formulations: – Tablets 400mg – Suppositories 250mg, 500mg Dose: – Acute 15mg/kg BD – or 10mg/kg TDS ( max 2.4g as a total daily dose ) Doses will or should…
Read MoreInfliximab Infusion
Drugs used in IBD Infliximab Infusion Infliximab is a monoclonal antibody which is used in the treatment of moderately to severe Crohns for the reduction of signs and symptoms which have shown an inadequate response to conventional therapy. It is also indicated for the treatment of fistulising Crohns disease in the reduction of the number…
Read MoreCyclosporin
Drugs used in IBD Cyclosporin Indication: Immunosuppressive therapy in Ulcerative colitis or Crohns disease. Formulations: Capsules 25mg, 50mg, 100mg Injection 50mg/ml Liquid 100mg/ml Enema (manufactured special) 50ml enema Dose: IV 1mg/kg BD adjust dosage according to levels Oral 2.5mg/kg BD adjust dosage according to levels Rectal 5mg/kg of cyclosporin suspension (Neoral) in 50ml of suspending…
Read MoreBudesonide (Entocort CR)
Drugs used in IBD Budesonide (Entocort CR) Indication: Mild to moderate Crohns disease affecting the ileum or ascending colon. Formulation: Capsules 3mg EC Dose: 1-5 years 3mg OD 6-10 years 6mg OD >10 years 9mg OD Give for 8 weeks, reducing the dose over the last 2 weeks. Side effects: Rare but include the following;…
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