Drugs used to treat GORD Sucralfate Prophylaxis of stress ulceration Indication: Prophylaxis of stress ulceration Formulation: Suspension 1g/5ml Tablets 1g Dose: 0-2yrs 250mg 4-6hrly 3-12yrs 500mg 4-6hrly >12yrs 1g 4-6hrly Side-effects: Constipation, diarrhoea, nausea, indigestion, dry mouth, rash and dizziness Interactions: Decreased levels of tetracyclines, ciprofloxacin, phenytoin, cimetidine, digoxin, warfarin, thyroxine and ketoconazole. BOOK AN…

Drugs used to treat GORD Ranitidine Reduces gastric acid secretion Indication: Reduces gastric acid secretion Formulations: Tablets 150mg, 300mg Dispersible tabs 150mg Syrup 15mg/ml Injection 50mg/2ml Dose: Oral <6 months 1- 3mg/kg tds 6 months – 8 years 2-4mg/kg either bd or tds (max total daily dose 300mg) >8 yrs 150mg bd Side-effects: Headache, rash,…

Drugs used to treat GORD Omeprazole Proton pump inhibitor Reduces gastric acid secretion Indication: Proton pump inhibitor Reduces gastric acid secretion Formulation: Dispersible tablet 10mg, 20mg Injection 40mg (named patient) Suspension 2mg/ml (special in 8.4% sodium bicarbonate with a 30 day expiry if stored in the fridge) Dose: 0.7-1.4mg/kg (max 40mg) od to bd May…

Drugs used to treat GORD Metoclopramide Anti emetic use only. Indication: Anti emetic use only. Formulations: Solution 1mg/ml Tablets 10mg Dose: 0.1-0.2mg/kg 6-8 hrly. Side effects: Increased gastric motility, extrapyramidal side effects, drowsiness and restlessness. Interactions: Increased effects of paracetamol Opiates and antimuscarinics decrease the effects of metoclopramide Increased risk of extrapyramidal effects with tetrabenazine.…

Drugs used in constipation Domperidone Used in some situations but its clinical evidence base is poor. Indication: Treatemnt of GORD Formulation: Suspension 1mg/ml Tablet 10mg Suppository 30mg Dose: Oral 0.2-0.4mg/kg tds – qds (can increase to 0.6mg/kg tds – qds) Rectal 1mg/kg (max tds) round to nearest possible dose Side-effects: Rash, extra pyramidal effects Interactions:…