Treatment of mild to moderate Ulcerative colitis and Crohns disease
Tablets 500mg, 500mg E/C
Acute 10-15mg/kg QDS (max 4-8g daily)
Doses will be adjusted to ensure ease of administration with the above formulations
Nausea, vomiting, diarrhoea, abdominal pain, headache, exacerbation of colitis symptoms, rarely reversible pancreatitis, hepatitis and interstitial nephritis, bone marrow suppression, fibrosing alveolitis.
Anaemia, folate deficiency and reversible oligospermia.
Stevens-Johnson syndrome, neurotoxicity, photosensitivity, proteinuria, haematuria, nephrotic syndrome.
Urine and contact lenses maybe stained orange.
Caution with G6PD deficiency and slow acetylators.
Caution if salicylate hypersensitive
May reduce the absorption of folic acid and digoxin
Blood and LFT’s should be performed regularly at the start of therapy.