Olsalazine

Indication:
Treatment of mild to moderate Ulcerative colitis and Crohns disease

Site of action:
Colon

Olsalazine consists of two molecules of mesalazine bound together. Colonic bacteria cleave this bond to release mesalazine.

Formulations:
Capsules 250mg, 500mg

Dose:
Acute 20mg/kg BD
or 13mg/kg TDS ( max 3g as a total daily dose )

Doses will be adjusted to ensure ease of administration with the above formulations

Side-effects:
Diarrhoea, arthralgia, rash and blood dyscrasias.

Interactions:
None known

Notes:
Gastrointestinal side-effects such as diarrhoea are the most commonest side-effects and these can be reduced if the dose is taken with meals.

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