Budesonide (Entocort CR)

Indication:
Mild to moderate Crohns disease affecting the ileum or ascending colon.

Formulation:
Capsules 3mg EC

Dose: 1-5 years 3mg OD
6-10 years 6mg OD
>10 years 9mg OD
Give for 8 weeks, reducing the dose over the last 2 weeks.

Side effects:
Rare but include the following; Dyspepsia, peptic ulceration, myopathy, osteoporosis, adrenal supression, hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite, immunosupression, fluid and electrolyte disturbances.

Interactions:
Rare but include the following; NSAID’s – increased risk of bleeding
Carbamazepine, Phenobarbitone, Phenytoin – increased rate of metabolism of steroid.
Cyclosporin – increased prednisolone levels with increased cyclosporin levels with high dose methylprednisolone.
Diuretics – increased risk of hypokalaemia.

Notes:
The contents of the capsule may be emptied and swallowed whole.

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