Omeprazole

Proton pump inhibitor
Reduces gastric acid secretion

Indication:
Proton pump inhibitor
Reduces gastric acid secretion

Formulation:
Dispersible tablet 10mg, 20mg
Injection 40mg (named patient)
Suspension 2mg/ml (special in 8.4% sodium bicarbonate with a 30 day expiry if stored in the fridge)

Dose:
0.7-1.4mg/kg (max 40mg) od to bd
May increase to 3.5mg/kg daily
Twice daily dosing maybe more effective in some patients.
<2ys: 5mg od (not licensed therefore discuss with paeds gastro
team)
2-6yrs: 10mg od
>6yrs: 20mg od
RFH may use quite aggressive doses in order to suppress acid secretion

Side-effects:
Rash, alopecia, diarrhoea, headache, nausea, constipation, flatulence and dizziness.

Interactions:
Warfarin, phenytoin and diazepam will have increased levels.
Decreased levels seen in ketoconazole.

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Drug therapy of gastro-oesphageal reflux

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