Domperidone

Used in some situations but its clinical evidence base is poor.

Indication:
Treatemnt of GORD

Formulation:
Suspension 1mg/ml
Tablet 10mg
Suppository 30mg

Dose:
Oral 0.2-0.4mg/kg tds – qds (can increase to 0.6mg/kg tds – qds)
Rectal 1mg/kg (max tds) round to nearest possible dose

Side-effects:
Rash, extra pyramidal effects

Interactions:
Opiates decrease the effect of domperidone
Antimuscarinics decrease the effect of domperidone

Notes:
Extra-pyramidal
side effects may occur such as jerking or abnormal movements.

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Drug therapy of gastro-oesphageal reflux

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