Treatment of mild to moderate Ulcerative colitis and Crohns disease
Site of action:
Olsalazine consists of two molecules of mesalazine bound together. Colonic bacteria cleave this bond to release mesalazine.
Capsules 250mg, 500mg
Acute 20mg/kg BD
or 13mg/kg TDS ( max 3g as a total daily dose )
Doses will be adjusted to ensure ease of administration with the above formulations
Diarrhoea, arthralgia, rash and blood dyscrasias.
Gastrointestinal side-effects such as diarrhoea are the most commonest side-effects and these can be reduced if the dose is taken with meals.