Budesonide (Entocort CR)
Mild to moderate Crohns disease affecting the ileum or ascending colon.
Capsules 3mg EC
Dose: 1-5 years 3mg OD
6-10 years 6mg OD
>10 years 9mg OD
Give for 8 weeks, reducing the dose over the last 2 weeks.
Rare but include the following; Dyspepsia, peptic ulceration, myopathy, osteoporosis, adrenal supression, hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite, immunosupression, fluid and electrolyte disturbances.
Rare but include the following; NSAID’s – increased risk of bleeding
Carbamazepine, Phenobarbitone, Phenytoin – increased rate of metabolism of steroid.
Cyclosporin – increased prednisolone levels with increased cyclosporin levels with high dose methylprednisolone.
Diuretics – increased risk of hypokalaemia.
The contents of the capsule may be emptied and swallowed whole.