Reduce inflammation in acute attacks of Crohns and Ulcerative colitis.
Maintain remission of the above.

Prednisolone Tabs 1mg, 5mg, 25mg
Soluble 5mg
Methylprednisolone succinate Inj 40mg, 125mg, 500mg, 1g

Acute inflammation.
Prednisolone 2mg/kg daily (max 40mg)
(if used >7days, decrease over 14 days)

Hydrocortisone is required to cover periods where the patient is to be nil by mouth or in the post operative period.
Acute inflammation: 50mg qds
Peri-operative cover: 20mg qds
Side effects: Dyspepsia, peptic ulceration, myopathy, osteoporosis, adrenal suppression, hirsutism, weight gain, negative nitrogen and calcium balance, increased appetite, immunosupression, fluid and electrolyte disturbances.

NSAIDs – increased risk of bleeding
Carbamazepine, Phenobarbitone, Phenytoin – increased rate of metabolism of steroid.
Cyclosporin – increased prednisolone levels with increased cyclosporin levels with high dose methylprednisolone.
Diuretics – increased risk of hypokalaemia.

Methylprednisolone succinate is indicated for IV therapy, not methylprednisolone acetate.
Converting methylprednisolone to prednisolone, reduce dose by 20%.

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