Proton pump inhibitor Reduces gastric acid secretion
Proton pump inhibitor
Reduces gastric acid secretion
Dispersible tablet 10mg, 20mg
Injection 40mg (named patient)
Suspension 2mg/ml (special in 8.4% sodium bicarbonate with a 30 day expiry if stored in the fridge)
0.7-1.4mg/kg (max 40mg) od to bd
May increase to 3.5mg/kg daily
Twice daily dosing maybe more effective in some patients.
<2ys: 5mg od (not licensed therefore discuss with paeds gastro
2-6yrs: 10mg od
>6yrs: 20mg od
RFH may use quite aggressive doses in order to suppress acid secretion
Rash, alopecia, diarrhoea, headache, nausea, constipation, flatulence and dizziness.
Warfarin, phenytoin and diazepam will have increased levels.
Decreased levels seen in ketoconazole.